Rheumatoid arthritis and the risk of ischaemic stroke after diagnosis of atrial fibrillation: a Norwegian nationwide register study
Authors' conclusion
RA patients diagnosed with AF are at a further increased risk for stroke compared with non-RA patients with AF, and less likely to receive OAC treatment
Study context
- Population
- Patients with a first atrial fibrillation (AF) diagnosis, nationwide Norwegian Cardio-Rheuma Register, 2010–2017
- Participants
- 2,750 vs 158,879
- Exposure
- AF patients with RA vs AF patients without RA
- RAn = 2,750
- Non-RAn = 158,879reference
- Outcome
- Ischaemic stroke after the first AF diagnosis (cumulative incidence and hazard rate)
Methodological detailscompeting risk model, 3-month delayed entry
- Competing risk model
- 3-month delayed entry
Main finding
As reported in the abstract
Ischaemic stroke after AF diagnosis
RA vs Non-RAEstimate (95% CI)
Ischaemic stroke after AF diagnosis
HR (unadjusted) 1.36(1.13–1.62)
Unchanged after further adjustment for diabetes, hypertension, atherosclerotic CVD and OAC treatment
HR (sex- and age-adjusted) 1.25(1.05–1.50)
Observational data: associations, not effects.
Further findings
| Outcome | aOR (95% CI) | |
|---|---|---|
| Receipt of OAC treatment | 0.88 (0.80–0.97) | |
| 0.512Adjusted odds ratio (log scale) |
Original publication
Rheumatoid arthritis and the risk of ischaemic stroke after diagnosis of atrial fibrillation: a Norwegian nationwide register study. Rheumatology (Oxford). Published 22 August 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →