Health-Related Quality of Life in Disease-Modifying Antirheumatic Drug–Treated Adults With Juvenile Idiopathic Arthritis Compared to Rheumatoid Arthritis and the General Population
Authors' conclusion
Compared to patients with RA and the general population, patients with JIA had lower physical HRQOL 6 months after DMARD initiation. Mental health composite scores were similar among patients with JIA, those with RA, and the general population. Both disease groups showed similar levels of improvement with treatment.
Study context
- Population
- Adults with juvenile idiopathic arthritis (JIA) and rheumatoid arthritis (RA) starting or switching disease-modifying antirheumatic drug (DMARD) treatment in the Norwegian DMARD Register (NOR-DMARD)at 6 months follow-up
- Exposure
- JIA vs RA and the general Norwegian population
- JIAn = 232
- RAn = 2,764
- Outcome
- Health-related quality of life (HRQOL) by SF-36, SF-36 PCS, SF-36 MCS and SF-6D
- Follow-up
- 6 months
Methodological detailsage- and gender-adjusted regression analyses, 6-month follow-up
- Age- and gender-adjusted regression analyses
- 6-month follow-up
Main finding
As reported in the abstract
SF-36 PCS, adjusted difference
Adjusted difference (95% CI)
JIAvs RA
−3.58(−6.09 to −1.08)
JIAvs General population
−15.70(−18.21 to −13.19)
RAvs General population
−12.12(−12.76 to −11.47)
Observational data: associations, not effects.
Further findings
Improvement exceeding minimum clinically important difference (MCID) in SF-36 scale scores, physical component summary (PCS), mental component summary (MCS) and SF-6D · 6 months
- Similar proportions in JIA and RA
Original publication
Health-Related Quality of Life in Disease-Modifying Antirheumatic Drug–Treated Adults With Juvenile Idiopathic Arthritis Compared to Rheumatoid Arthritis and the General Population. J Rheumatol. Published 1 September 2025. doi:10.
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