Treatment Response to Tumor Necrosis Factor Inhibitors and Methotrexate Monotherapy in Adults With Juvenile Idiopathic Arthritis: Data From NOR-DMARD
Authors' conclusion
TNFi and MTX monotherapy are effective in adult JIA, with similar effectiveness to that shown in RA.
Study context
- Population
- Adult patients with juvenile idiopathic arthritis (JIA) and rheumatoid arthritis (RA) from the Norwegian Antirheumatic Drug Register (NOR-DMARD)478 JIA, 4637 RA
- Participants
- 358 / 2,292 / 120 / 2,345
- Exposure
- Adult JIA vs RA starting tumor necrosis factor inhibitors (TNFi) or methotrexate (MTX) monotherapy
- JIA TNFin = 358
- RA TNFin = 2,292reference
- JIA MTX monotherapyn = 120
- RA MTX monotherapyn = 2,345reference
- Outcome
- Change in disease activity (DAS28, Clinical Disease Activity Index (CDAI), Simplified Disease Activity Index (SDAI), among others) from baseline
- Follow-up
- 3, 6 and 12 months
Methodological detailsage- and gender-weighted analyses, adjusted for baseline disease activity, LUNDEX-corrected rates
- Age- and gender-weighted analyses
- Adjusted for baseline disease activity
- LUNDEX-corrected rates
Main finding
As reported in the abstract
Change in disease activity from baseline
- After baseline disease activity adjustment, no significant differences between JIA and RA for either treatment group
- Adjusted for baseline disease activity
Observational data: associations, not effects.
Further findings
DAS28 remission · 12 months
ACR/EULAR remission · 12 months
Drug survival
Baseline disease activity
- Lower in JIA than RA across treatment groups
DAS28 remission · 12 months
- Similar between groups
American College of Rheumatology (ACR)/EULAR remission · 12 months
- Similar between groups
Drug survival
- Similar for JIA and RA in both treatment groups
Original publication
Treatment Response to Tumor Necrosis Factor Inhibitors and Methotrexate Monotherapy in Adults With Juvenile Idiopathic Arthritis: Data From NOR-DMARD. J Rheumatol. Published 15 November 2022. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →