Impact of Sex, Serostatus, and Smoking on Risk for Rheumatoid Arthritis–Associated Interstitial Lung Disease Subtypes
Authors' conclusion
Older age, seropositivity, and male sex were strongly associated with RA-UIP, whereas RA-related autoantibodies were associated with RA-NSIP.
Study context
- Population
- Patients with RA in the Brigham RA Sequential Study and Mass General Brigham Biobank RA cohortpatients with RA screened
- Participants
- 3,328 patients
- Comparison
- RA-ILD subtypes vs RA controls without ILD
- RA-ILDn = 208
- RA-noILDn = 547reference
- Outcome
- Associations of demographic, lifestyle and serologic factors with RA-ILD subtypes
Methodological detailsmultivariable logistic regression, RA-ILD subtype by chest high-resolution CT imaging pattern
- Multivariable logistic regression
- RA-ILD subtype by chest high-resolution CT imaging pattern
Main finding
As reported in the abstract
Risk factors for RA-ILD subtypes
- RA-UIP: older age, OR per year
- 1.03 (95% CI 1.01-1.05)
- RA-UIP: male sex, OR
- 2.15 (95% CI 1.33-3.48)
- RA-UIP: seropositivity, OR
- 2.08 (95% CI 1.24-3.48)
- RA-NSIP: seropositive status, OR (95% CI 1.36-7.56); only significant association
- 3.21
- Nonfibrotic ILDs: smoking, OR
- 2.81 (95% CI 1.52-5.21)
Observational data: associations, not effects.
Further findings
RA-UIP with three RA-ILD risk factors (male, seropositive, smoking) vs none
- OR
- 6.89 (95% CI 2.41-19.7)
Original publication
Impact of Sex, Serostatus, and Smoking on Risk for Rheumatoid Arthritis–Associated Interstitial Lung Disease Subtypes. Arthritis Care Res (Hoboken). Published 16 October 2024. doi:10.
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