Plasma metabolomics and incident major adverse cardiovascular events in patients with rheumatoid arthritis
Authors' conclusion
In this first metabolomic study in RA, we identified a distinct cardiovascular risk profile. Higher levels of large HDL particles were associated with increased risk, whereas small HDL particles were associated with lower risk
Study context
- Population
- Mass General Brigham Biobank participants with RA, without known CVD and no statin use at blood draw (mean age 62 years; 80% women)RA
- Participants
- 1,271 participants
- Exposure
- Plasma metabolite levels and incident MACE in RA, compared with matched non-RA controls
- RAn = 1,271
- Outcome
- Incident MACE:
- MI
- Stroke
- Transient ischaemic attack
- Death
Methodological details1:2 matched non-RA control cohort, multivariable Cox models, false discovery rate correction
- 1:2 matched non-RA control cohort
- Multivariable Cox models
- False discovery rate correction
Main finding
As reported in the abstract
Plasma metabolites associated with incident MACE:
- Cox models
- FDR-corrected
Plasma metabolites significantly associated with MACE
25
Incident MACE
8%
Observational data: associations, not effects.
Further findings
Comparison with matched non-RA controls
- Several associations unique to RA; distinct metabolomic risk profile involving triglyceride-rich VLDL and HDL particles
Original publication
Plasma metabolomics and incident major adverse cardiovascular events in patients with rheumatoid arthritis. Rheumatology (Oxford). Published 31 July 2026. doi:10.
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