Menopause status and its role in incident Alzheimer’s disease and related dementias, rheumatoid arthritis (RA) disease severity, and overall mortality in women with RA
Authors' conclusion
Women with early/premature and late menopause had nonsignificant, increased risk of incident ADRD.
Study context
- Population
- Women with incident RA in 1980–2014 aged ≥50 years at RA incidence
- Exposure
- Menopausal characteristics
- Outcome
- Incident ADRD
Methodological detailspopulation-based (Rochester Epidemiology Project), Cox models, mixed-effects models
- Population-based (Rochester Epidemiology Project)
- Cox models
- Mixed-effects models
Main finding
As reported in the abstract
- Early/premature and late menopause associated with nonsignificant near two-fold increases in and related dementias (ADRD) risk
Observational data: associations, not effects.
Further findings
Severe ExRA
| HR for severe ExRA (95% CI) | ||
|---|---|---|
| Early/premature menopause | 2.40 (1.15–5.01) | |
| Late menopause | 2.17 (1.01–4.66) | |
| 0.20.5125HR for severe ExRA (log scale) |
Clinic visits for RA remission (early/premature menopause)
| OR for a remission visit (fewer remission visits) (95% CI) | ||
|---|---|---|
| Early/premature menopause | 0.50 (0.29–0.87) | |
| 0.20.5125OR for a remission visit (fewer remission visits) (log scale) |
Erosions and mortality
- Menopausal characteristics not associated with presence of erosions or mortality
CV events and RA remission visits (artificial menopause)
- Artificial menopause associated with fewer CV events and fewer visits for RA remission
Original publication
Menopause status and its role in incident Alzheimer’s disease and related dementias, rheumatoid arthritis (RA) disease severity, and overall mortality in women with RA. Semin Arthritis Rheum. Published 30 July 2026. doi:10.
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