Role of rheumatoid arthritis flare in the risk of Alzheimer’s disease and related dementias: a population-based cohort study
Main finding · Incident AD/ADRD, definition 1Result — go to the resultHazard ratio 1.11 95% CI 0.63–1.96Authors' conclusion
We found that RA flares are common. A detrimental effect of active flares on cognitive status cannot be excluded.
Study context
- Population
- Inception cohort of rheumatoid arthritis (RA) patients aged ≥ 50 years, residents of Minnesota, USA (1988–2014)median follow-up 7.8 years
- Participants
- 774 participants
- Exposure
- RA flare vs remission
- Outcome
- Incident AD/ADRD (two ICD-9/10 codes ≥ 30 days apart)
Methodological detailsinception cohort, medical record review, Cox models
- Inception cohort
- Medical record review
- Cox models
Main finding
Incident AD/ADRD, definition 1
Hazard ratio
1.11
95% CI 0.63–1.96
Flarevs Remission
HR 1.11 (95% CI 0.63–1.96)
As reported in the abstract
Observational data: associations, not effects.
Further findings
| Outcome | HR (95% CI) | |
|---|---|---|
| Incident AD/ADRD, definition 2 (acute flares)Flarevs Remission | 1.82 (0.82–4.06) | |
| 0.20.5125Hazard ratio (log scale) |
| Outcome | Remission |
|---|---|
| Flare and remission status at medical visits (12 437 visits) | 23.3% |
- Flare and remission status at medical visits (12 437 visits): Flare 27.4%
Incident AD/ADRD, whole cohort · median follow-up 7.8 years
- Patients who developed AD/ADRD
- 79 (10%)
Original publication
Role of rheumatoid arthritis flare in the risk of Alzheimer’s disease and related dementias: a population-based cohort study. Scand J Rheumatol. Published 3 June 2025. doi:10.
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