Pulmonary function trajectories in rheumatoid arthritis-associated interstitial lung disease
Authors' conclusion
The rate of pulmonary function decline was similar for corticosteroid-treated and untreated patients, although treated patients had significantly lower pulmonary function.
Study context
- Population
- Patients with RA-ILD
- Participants
- 101 patients
- Exposure
- Oral corticosteroid therapy for interstitial lung disease (ILD) vs no corticosteroid therapy
- Outcome
- Pulmonary function trajectories: change in forced vital capacity (FVC) and DLCO per 30 days
Methodological detailsmultiple regression model with linear time trend and individual random coefficients for intercept and slope
- Multiple regression model with linear time trend and individual random coefficients for intercept and slope
Main finding
As reported in the abstract
Change in FVC per 30 days
Treated
−0.10
95% CI −0.18–-0.04
Untreated
−0.13
95% CI −0.19–-0.07
Observational data: associations, not effects.
Further findings
| Outcome | Treated | Untreated | Between-group difference (95% CI) | P value | |
|---|---|---|---|---|---|
| Change in DLCO per 30 days | — not stated in the abstract | −0.10 (95% CI −0.14–-0.05) | 0.0007 (−0.07 to 0.07) | P = 0.985 | |
| −0.1−0.0500.050.1Difference (linear scale) |
— not stated in the abstract
Mean FVC
Mean DLCO
Adjustment for radiographic pattern
- Inclusion of radiographic pattern did not change the results
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Pulmonary function trajectories in rheumatoid arthritis-associated interstitial lung disease. Scand J Rheumatol. Published 3 June 2025. doi:10.
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