Risk of total and cause-specific mortality in patients with rheumatoid arthritis-associated interstitial lung disease or bronchiectasis
Main finding · Total mortality (per 1000 person-years)Result — go to the resultHazard ratio 1.97 95% CI 1.43–2.70Authors' conclusion
RA-LD, particularly RA-ILD, is associated with higher mortality, especially respiratory and infection-related mortality. RA-BR is associated with increased respiratory and cancer mortality.
Study context
- Population
- RA patients in the Mass General Brigham Biobank (Boston, MA)matched cohort
- Participants
- 221 / 151 / 70 / 980
- Exposure
- RA-associated lung disease vs RA without lung disease
- RA-LDn = 221
- RA-associated interstitial lung disease (RA-ILD)n = 151
- RA-associated bronchiectasis (RA-BR)n = 70
- RA-no LDn = 980reference
- Outcome
- Total and cause-specific mortality (respiratory, cancer, cardiovascular, infection)
Methodological detailsmatched by calendar date, age, sex and RA duration, propensity score-adjusted, Cox regression, Fine and Gray models
- Matched by calendar date, age, sex and RA duration
- Propensity score-adjusted
- Cox regression
- Fine and Gray models
Main finding
Total mortality (per 1000 person-years)
Hazard ratio
1.97
95% CI 1.43–2.70
By group
RA-LDvs RA-no LD
HR 1.97 (95% CI 1.43–2.70)
As reported in the abstract
Observational data: associations, not effects.
Further findings
Per 1000 person-years
| Outcome | RA-LD | RA-BR | RA-no LD | sdHR (95% CI) | |
|---|---|---|---|---|---|
| Respiratory mortality (per 1000 person-years)RA-LDvs RA-no LDParticularly in RA-ILD patients | 13.1 | — not stated in the abstract | 1.7 | 6.68 (3.19–14.00) | |
| Lung infection-related mortality (per 1000 person-years)RA-LDvs RA-no LDParticularly in RA-ILD patients | 6.3 | — not stated in the abstract | 1.4 | 3.33 (1.32–8.37) | |
| Cancer mortality in RA-BR (per 1000 person-years)RA-BRvs RA-no LD | — not stated in the abstract | 8.6 | 2.3 | 2.89 (1.11–7.47) | |
| 0.050.21520Subdistribution hazard ratio (log scale) |
— not stated in the abstract
| Outcome | RA-LD | RA-BR | RA-no LD | P value |
|---|---|---|---|---|
| Infection-related mortalityRA-LD vs RA-no LD | 7% | — not stated in the abstract | 3% | P = 0.002 |
— not stated in the abstract
Original publication
Risk of total and cause-specific mortality in patients with rheumatoid arthritis-associated interstitial lung disease or bronchiectasis. Rheumatology (Oxford). Published 11 July 2025. doi:10.
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