Hospitalization risk in patients with rheumatoid arthritis-associated interstitial lung disease or bronchiectasis: A matched cohort study
Authors' conclusion
RA-ILD and RA-BR were each associated with markedly higher risks of overall and respiratory hospitalization than RA-no LD comparators.
Study context
- Population
- Patients with RA-associated lung disease and matched RA comparators, Mass General Brigham Biobank (Boston, Massachusetts)matched cohort
- Participants
- 221 / 151 / 70 / 980
- Exposure
- RA-LD vs matched RA comparators without lung disease
- RA-LDn = 221
- RA-associated interstitial lung disease (RA-ILD)n = 151
- RA-associated bronchiectasis (RA-BR)n = 70
- RA-no LDn = 980reference
- Outcome
- Co-primary: overall and respiratory hospitalizations
Methodological detailsmatched, propensity score-adjusted, multivariable Poisson regression
- Matched
- Propensity score-adjusted
- Multivariable Poisson regression
Main finding
As reported in the abstract
RA-LD vs RA-no LDAdjusted incidence rate ratio (95% CI)
Overall hospitalization
1.73(1.57–1.91)
Respiratory hospitalization
5.13(3.80–6.94)
Observational data: associations, not effects.
Further findings
| Outcome | Adjusted IRR (95% CI) | |
|---|---|---|
| ICU admissionsRA-ILDvs RA-no LD | 1.99 (1.81–2.18) | |
| 0.512Adjusted incidence rate ratio (log scale) |
Factors associated with respiratory hospitalization
- MUC5B promoter variant and GC use each associated with higher respiratory hospitalization risk
- More frequent clinic visits and female sex associated with lower risk
Original publication
Hospitalization risk in patients with rheumatoid arthritis-associated interstitial lung disease or bronchiectasis: A matched cohort study. Semin Arthritis Rheum. Published 8 May 2026. doi:10.
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