Serum biochemical marker of synovial tissue turnover, C1M, predicts radiological progression in early rheumatoid arthritis
Authors' conclusion
High baseline serum C1M, but not C2M, is associated with increased radiographic progression in early arthritis, independently of classical risk factors.
Study context
- Population
- Early arthritis patients (<6 months of symptoms, 82% RA, 18% undifferentiated arthritis) from the prospective ESPOIR studyfollowed for 5 years
- Participants
- 813 patients
- Exposure
- Highest vs lowest quartile of baseline serum C1M
- Outcome
- Radiographic progression (van der Heijde Sharp score increase of 1 or 5 unit(s))
- Follow-up
- 1 year or 5 years
Methodological detailslogistic regression, 5-year follow-up
- Logistic regression
- 5-year follow-up
Main finding
As reported in the abstract
Total joint damage progression · 1 year
C1M highest quartile vs C1M lowest quartileOdds ratio (95% CI)
Adjusted for age, gender and BMI
2.75(1.70–4.45)
Further adjusted for DAS28, CRP and anti-CCP2 positivity
2.12(1.06–4.23)
Observational data: associations, not effects.
Further findings
Total joint damage progression, C1M · 5 years
- C1M significantly associated with risk of progression after adjustment for age, gender and body mass index (BMI)
Progression, C2M · 1 year or 5 years
- No significant association of C2M with progression
Original publication
Serum biochemical marker of synovial tissue turnover, C1M, predicts radiological progression in early rheumatoid arthritis. RMD Open. Published 10 July 2025. doi:10.
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