Spondyloarthritis & psoriatic arthritis
Impact of patient characteristics on Axial Spondyloarthritis Disease Activity Score (ASDAS) disease activity state cut-offs in axial spondyloarthritis: results from nine European rheumatology registries
Authors' conclusion
Re-evaluation of ASDAS cut-offs for disease activity states in a large multi-national axSpA cohort resulted in cut-offs similar to those currently endorsed.
Study context
- Population
- Patients with axial spondyloarthritis (axSpA) starting their first TNFi in nine European registries
- Participants
- 2,939 patients
- Outcome
- ASDAS cut-offs separating disease activity states (ID, LDA, HDA, very high disease activity)
Methodological detailsnine European registries, ROC analyses against external criteria
- Nine European registries
- ROC analyses against external criteria
Main finding
As reported in the abstract
ASDAS cut-offs, overall population
Cut-off inactive disease (ID) vs low disease activity (LDA)
<1.3
Cut-off LDA vs high disease activity (HDA)
<2.0
Cut-off HDA vs very high disease activity
>3.5
Observational data: associations, not effects.
Further findings
ASDAS cut-offs for ID and LDA by sex
- Women: ID cut-off
- <1.5
- Women: LDA cut-off
- <2.0
- Men: ID cut-off
- <1.3
- Men: LDA cut-off
- <1.9
ASDAS cut-offs for ID and LDA by age
- ≥45 years: ID cut-off
- <1.5
- ≥45 years: LDA cut-off
- <2.2
- ≤34 years: ID cut-off
- <1.2
- ≤34 years: LDA cut-off
- <1.9
- 35-44 years: ID cut-off
- <1.3
- 35-44 years: LDA cut-off
- <1.8
Cut-offs by calendar time and disease duration
- Cut-offs were independent of calendar time and disease duration
Original publication
Impact of patient characteristics on ASDAS disease activity state cut-offs in axial spondyloarthritis: results from nine European rheumatology registries. RMD Open. Published 2 November 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →