Lupus & antiphospholipid syndrome
Impact of glucocorticoid tapering speed on renal outcomes in proliferative lupus nephritis: a multicentre retrospective study
Authors' conclusion
Rapid GC reduction to ≤7.5 mg/day within 6 months did not compromise renal outcomes or increase relapse in proliferative LN.
Study context
- Population
- Glucocorticoid (GC)-naïve patients with biopsy-proven proliferative LN with urinary protein-to-creatinine ratio (UPCR) data before and 52 weeks after GC treatment, 17 centres
- Participants
- 344 patients17 centres
- Exposure
- Rapid GC reduction vs conventional GC reduction
- Rapid GC reducersn = 50
- Conventional GC reducersn = 294reference
- Outcome
- Partial renal response (PRR)
- Follow-up
- 12 months
Methodological detailsmulticentre, retrospective chart review, modified Poisson regression
- Multicentre
- Retrospective chart review
- Modified Poisson regression
Main finding
As reported in the abstract
PRR
Observational data: associations, not effects.
Further findings
Relapse rates · 2 years
- Comparable between the groups
Safety
Serious adverse events · 2 years
- Comparable between the groups
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Impact of glucocorticoid tapering speed on renal outcomes in proliferative lupus nephritis: a multicentre retrospective study. Rheumatology (Oxford). Published 13 May 2025. doi:10.
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