Autoinflammatory & rare systemic diseases
Immunohistochemical expression of DnaJ homolog subfamily B member 9 in immunoglobulin G4-related disease: a pilot study
Authors' conclusion
Our findings evidenced reduced immunohistochemical expression of DNAJB9 in IgG4-RD endothelial cells, and suggested loss of expression in other cell types, possibly correlating with disease severity and risk of relapse.
Study context
- Population
- Tissue slides of patients with definite immunoglobulin G4-related disease (IgG4-RD) and normal tissue controls, including salivary gland, pancreatic, pulmonary, pleural, and retroperitoneal fibrosis tissue
- Participants
- 9 vs 15
- Comparison
- IgG4-RD tissue specimens vs normal tissue controls
- IgG4-RDn = 9
- Controlsn = 15reference
- Outcome
- Immunohistochemical distribution and intensity of DNAJB9 (semi-quantitative staining intensity score)
Methodological detailssemi-quantitative staining intensity score
- Semi-quantitative staining intensity score
Main finding
As reported in the abstract
DNAJB9 immunohistochemical intensity, endothelial cells
ES
1.58
P < 0.01
By group
IgG4-RD
0
Median
Controls
2
Median
Further findings
Median
| Outcome | IgG4-RD | Controls | ES | P value |
|---|---|---|---|---|
| DNAJB9 immunohistochemical intensity, glandular epithelial cells | 2 | — not stated in the abstract | 0.70 | P = 0.26 |
| DNAJB9 immunohistochemical intensity, inflammatory cells (salivary glands alone) | 2 | 3 | 0.90 | P = 0.11 |
— not stated in the abstract
Correlation of endothelial staining intensity with serum IgG4 concentrations and number of treatments to achieve remission
- Correlation with serum IgG4 concentrations (r), p=0.03
- −0.72
- Correlation with number of treatments required to achieve remission (r), p=0.04
- −0.70
Original publication
Immunohistochemical expression of DnaJ homolog subfamily B member 9 in immunoglobulin G4-related disease: a pilot study. Clin Exp Rheumatol. Published 29 June 2023. doi:10.
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