Autoinflammatory & rare systemic diseases
Differential CpG DNA methylation of peripheral B cells, CD4+ T cells, and salivary gland tissues in IgG4-related disease
Authors' conclusion
Our findings highlighted the role of epigenetic modification of DNA methylation and identified several genes and pathways possibly involved in IgG4-RD pathogenesis.
Study context
- Population
- Immunoglobulin-G4-related disease (IgG4-RD) patients and matched controls; peripheral B cells, CD4+ T cells and salivary gland tissues
- Comparison
- IgG4-RD patients vs matched controls
- Outcome
- Differentially methylated CpG sites (DMPs)
Methodological detailsgenome-wide DNA methylation (Illumina HumanMethylation 850K BeadChip), matched controls, pyrosequencing and immunohistochemistry validation
- Genome-wide DNA methylation (Illumina HumanMethylation 850K BeadChip)
- Matched controls
- Pyrosequencing and immunohistochemistry validation
Main finding
As reported in the abstract
DMPs, IgG4-RD vs controls
- B cells (10 IgG4-RD vs 10 healthy controls): hypomethylated differentially methylated probes (DMPs)
- 44
- B cells: hypermethylated DMPs
- 166
- CD4+ T cells (10 vs 10): hypomethylated DMPs
- 260
- CD4+ T cells: hypermethylated DMPs
- 112
- Salivary gland tissues (4 IgG4-RD vs 4 controls): hypomethylated DMPs
- 36945
- Salivary gland tissues: hypermethylated DMPs
- 78380
Original publication
Differential CpG DNA methylation of peripheral B cells, CD4+ T cells, and salivary gland tissues in IgG4-related disease. Arthritis Res Ther. Published 7 January 2023. doi:10.
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