Autoinflammatory & rare systemic diseases
Diagnostic value of a novel salivary gland ultrasound scoring system in IgG4-related sialadenitis
Authors' conclusion
A novel semiquantitative ultrasound scoring system for patients with IgG4-RS was developed, with good diagnostic performance.
Study context
- Population
- Multicentre cohort of Chinese patients with suspected IgG4-related sialadenitis
- Participants
- 470 participants
- Comparison
- Immunoglobulin G4-related sialadenitis (IgG4-RS) vs non-IgG4-RS
- IgG4-RSn = 187
- non-IgG4-RSn = 283reference
- Outcome
- Diagnostic value of a novel salivary gland US scoring system (total score 0 to 34) for IgG4-RS
Methodological detailsmulticentre
- Multicentre
Performance
As reported in the abstract
Diagnostic performance of total US score
IgG4-RS
16
mean
non-IgG4-RS
4
mean
P < 0.001
- AUC for total ultrasonography (US) score
- 0.852 (95% CI: 0.814, 0.891)
- Sensitivity at total US score ≥9
- 75.4%
- Specificity at total US score ≥9
- 91.9%
Further findings
Reliability of US scoring system
- Inter-reader reliability (excellent)
- 0.972
- Intra-reader reliability (excellent)
- 0.940
Correlation of total US score with laboratory features
- Serum IgG4 levels, positive correlation
- r = 0.221, P = 0.002
- Hypocomplementaemia, positive correlation
- r = 0.349, P < 0.001
- Serum C3, negative correlation
- r = −0.210, P = 0.005
- Serum C4, negative correlation
- r = −0.303, P < 0.001
Original publication
Diagnostic value of a novel salivary gland ultrasound scoring system in IgG4-related sialadenitis. Rheumatology (Oxford). Published 1 March 2024. doi:10.
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