Autoinflammatory & rare systemic diseases
Comparing clinical features between males and females with VEXAS syndrome: data from literature analysis of patient reports
Authors' conclusion
Our results supported the hypothesis that the UBA1 mutation should be sought under the same conditions in both sexes.
Study context
- Population
- Patients with VEXAS syndrome with precise, individual VEXAS-related features described in previously published clinical descriptions104 articles
- Participants
- 224 patients
- Comparison
- Females vs males with VEXAS syndrome
- Womenn = 9
- Menn = 215reference
- Outcome
- Clinical and biological features of VEXAS syndrome by sex
Methodological detailsliterature-based cohort, individual patient data
- Literature-based cohort
- Individual patient data
Pooled result
As reported in the abstract
Clinical and biological features by sex
- No difference was observed in the clinical or biological features according to sex
Further pooled results
Type of UBA1 mutation and association with myelodysplastic syndrome
- No difference in the type of UBA1 mutation or the association with myelodysplastic syndrome
Karyotype among women
- Constitutional 45,X karyotype
- 1
- Acquired X monosomy in bone marrow karyotype
- 4
- Marrow karyotype not provided
Original publication
Comparing clinical features between males and females with VEXAS syndrome: data from literature analysis of patient reports. Rheumatology (Oxford). Published 24 February 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →