Autoinflammatory & rare systemic diseases
B cell subsets in adult-onset Still’s disease: potential candidates for disease pathogenesis and immunophenotyping
Authors' conclusion
B cell subsets are significantly altered in AOSD patients, potentially contributing to the disease pathogenesis.
Study context
- Population
- Adult-onset Still's disease (AOSD) patients and healthy controls (HCs); B cell subsets in peripheral blood
- Comparison
- AOSD patients vs healthy controls
- Outcome
- Frequencies of B cell subsets in peripheral blood
Methodological detailsflow cytometry, unbiased hierarchical clustering
- Flow cytometry
- Unbiased hierarchical clustering
Main finding
As reported in the abstract
Frequencies of peripheral blood B cell subsets, AOSD vs HCs
- Disease-promoting subsets (naïve B cells, DN B cells, plasmablasts) increased in AOSD
- Potential regulatory subsets (UM B cells, CD24hiCD27+ B10 cells) decreased in AOSD
Further findings
Correlation of altered B cell subsets with clinical features in AOSD
- Altered B cell subsets correlated with clinical and immunological features, e.g. immune cells, coagulation features, liver enzymes
B cell immunophenotyping clusters of AOSD patients
- Three groups: group 1 (naïve B cells-dominant), group 2 (CD27+ memory B cells-dominant), group 3 (precursors of autoantibody-producing plasma cells-dominant)
- The three groups differed in immune cells, liver or myocardial enzymes, coagulation features and systemic score
Original publication
B cell subsets in adult-onset Still’s disease: potential candidates for disease pathogenesis and immunophenotyping. Arthritis Res Ther. Published 15 June 2023. doi:10.
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