High-sensitivity cardiac troponin T in infants exposed to anti-Ro antibodies
Authors' conclusion
Only 3/45 anti-Ro antibodies-exposed infants had hs-cTnT values outside the reference range reported in healthy infants. None of 12 infants who had CMR had subclinical myocarditis/EFE.
Study context
- Population
- Consecutive infants exposed prenatally to anti-Ro antibodies seen at the SickKids neonatal lupus erythematosis (NLE) Clinic, 2012–2014
- Participants
- 45 consecutive infants
- Exposure
- Infants exposed prenatally to anti-Ro antibodies with vs without cardiac NLE
- Cardiac NLEn = 7
- Without cardiac NLEn = 38reference
- Outcome
- hs-cTnT levels (≥30 ng/l offered cardiac MRI)
Methodological detailsconsecutive infants, single-centre
- Consecutive infants
- Single-centre
Main finding
As reported in the abstract
hs-cTnT level ≥30 ng/l
Without cardiac NLE
25
events
Cardiac NLE
7
events
Observational data: associations, not effects.
Further findings
| Outcome | Cardiac NLE | Without cardiac NLE |
|---|---|---|
| hs-cTnT level >113 ng/l | 2/7 | 1 events |
| Steroid treatment adjusted based on hs-cTnT trend | 6/7 | — not stated in the abstract |
— not stated in the abstract
Cardiac MRI (CMR) findings in infants with high-sensitivity cardiac troponin T (hs-cTnT) ≥30 ng/l
- Without cardiac NLE: 8 underwent CMR, all without myocarditis/EFE
- Cardiac NLE: 4/7 had CMR, all without myocarditis/EFE
- None of 12 infants who had CMR had subclinical myocarditis/EFE
Original publication
High-sensitivity cardiac troponin T in infants exposed to anti-Ro antibodies. Rheumatology (Oxford). Published 13 March 2023. doi:10.
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