A 5–year follow-up of pulmonary function tests in childhood-onset systemic lupus erythematosus: a single-center retrospective study
Authors' conclusion
The most common PFT abnormalities seen in patients with cSLE are alterations in diffusing capacity as well as restrictive lung disease.
Study context
- Population
- Patients with childhood-onset SLE aged at least 6 years followed at a single centre, July 2015 to July 2020
- Participants
- 42 patients
- Outcome
- PFT abnormalities
Methodological detailssingle-centre, retrospective review
- Single-centre
- Retrospective review
Main finding
As reported in the abstract
Abnormal PFTs
Abnormal pulmonary function test (PFTs)
10
23.8%
Restrictive disease only
3
Diffusion impairment only
3
Both restrictive lung disease and diffusion impairment
4
Observational data: associations, not effects.
Further findings
Mean total lung capacity (TLC) in patients with restrictive patterns · throughout the study period
- Mean TLC
- 72.5 ± 5.8
Average DsbHb in patients with diffusion limitation · during the study period
- Average DsbHb
- 64.8 ± 8.3
Characteristics of patients with abnormal PFTs
- Mean age at diagnosis (years)
- 13 ± 2.9
- Female
- 9
Original publication
A 5–year follow-up of pulmonary function tests in childhood-onset systemic lupus erythematosus: a single-center retrospective study. Lupus. Published 13 March 2023. doi:10.
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