Systemic sclerosis & Raynaud's

Healthcare utilization in general practice and hospitals preceding a diagnosis of systemic sclerosis: a nationwide registry study

Rheumatology (Oxford)Published Population-based cohort study

Authors' conclusion

The higher use of healthcare services in general practice and hospitals in the three years before diagnosis suggests an opportunity to facilitate earlier diagnosis and treatment of SSc.

Study context

Population
Danish national registries: incident systemic sclerosis (SSc) patients diagnosed 2005–2018 and age- and gender-matched references without SSc1,255 women and 395 men with SSc
Participants
1,650 vs 16,500
Exposure
SSc vs matched references without SSc
  • SScn = 1,650
  • Referencesn = 16,500reference
Outcome
Healthcare utilization (contacts with general practice and hospitals) in the three years preceding diagnosis
Follow-up
Three years before diagnosis
Methodological detailsnationwide registry, matched by age and gender (1:10)
  • Nationwide registry
  • Matched by age and gender (1:10)

Main finding

As reported in the abstract

Each group vs referencesEstimate (95% CI)
SSc
adjusted IRR, general practice, women 1.43(1.33–1.53)
SSc
adjusted IRR, general practice, men 1.47(1.26–1.71)
SSc
adjusted IRR, hospitals, women 1.86(1.62–2.14)
SSc
adjusted IRR, hospitals, men 2.70(2.04–3.58)

Observational data: associations, not effects.

Further findings

OutcomeEstimate
Contacts with general practice and hospitals · Last three months before diagnosisSScvs Referencesadjusted IRR, general practice, women 2.30 (95% CI 2.16–2.44)
Contacts with general practice and hospitals · Last three months before diagnosisSScvs Referencesadjusted IRR, general practice, men 2.98 (95% CI 2.64–3.35)
Contacts with general practice and hospitals · Last three months before diagnosisSScvs Referencesadjusted IRR, hospitals, women 5.62 (95% CI 5.08–6.20)
Contacts with general practice and hospitals · Last three months before diagnosisSScvs Referencesadjusted IRR, hospitals, men 9.53 (95% CI 7.81–11.63)

Original publication

Healthcare utilization in general practice and hospitals preceding a diagnosis of systemic sclerosis: a nationwide registry study. Rheumatology (Oxford). Published 28 October 2024. doi:10.1093/rheumatology/keae597

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