Systemic sclerosis & Raynaud's
Clinical characteristics and clinical risk model of the lower gastrointestinal involvement in systemic sclerosis
Authors' conclusion
A clinical risk model of SSc-LGIT was established and it has demonstrated capability in predicting the risk of severe lower gastrointestinal involvement in systemic sclerosis.
Study context
- Population
- Systemic Sclerosis (SSc) patients admitted to Peking Union Medical College Hospital, December 2003 to December 2023matched 1:3
- Participants
- 42 vs 126
- Comparison
- SSc patients with lower gastrointestinal involvement (LGIT) vs matched SSc patients without LGIT
- SSc-LGITn = 42
- Controlsn = 126reference
- Outcome
- Risk factors of SSc-LGIT requiring hospitalisation and a clinical risk model
Methodological detailsmatched on age and gender (1:3), single-centre, machine learning risk model
- Matched on age and gender (1:3)
- Single-centre
- Machine learning risk model
Main finding
As reported in the abstract
Independent related factors for SSc-LGIT (multivariate analysis)
- Body mass index (BMI), cardiomyopathy, haemoglobin (HB), albumin (ALB) and hs-CRP were independent related factors for SSc-LGIT; a clinical risk model containing these five items was built
Observational data: associations, not effects.
Further findings
Clinical characteristics vs controls
- Lower BMI, haemoglobin and albumin in SSc-LGIT
- Cardiomyopathy and puffy finger more common, arthritis/arthralgia less common in SSc-LGIT
- Higher hs-CRP and higher rate of anti-Ro-52 antibody positivity in SSc-LGIT
Original publication
Clinical characteristics and clinical risk model of the lower gastrointestinal involvement in systemic sclerosis. Clin Exp Rheumatol. Published 25 October 2024. doi:10.
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