Systemic sclerosis & Raynaud's
Fatigue levels and associated factors in systemic sclerosis: a cross-sectional study of 2385 SPIN Cohort participants
Authors' conclusion
In people with SSc, fatigue scores were substantially higher than in the general population and associated with multiple disease factors, including gastrointestinal involvement, several painful disease manifestations, and lung involvement.
Study context
- Population
- Scleroderma Patient-centered Intervention Network (SPIN) Cohort participants with SSc (mean age 54.9 years, 87% female, 38% dcSSc)
- Participants
- 2,385 participants
- Exposure
- SSc cohort fatigue vs USA general population norms
- Outcome
- Fatigue T-score (PROMIS-29 v2.0 fatigue domain) vs USA general population (mean = 50; SD = 10)
Methodological detailsmultinational cohort, multivariable linear regression
- Multinational cohort
- Multivariable linear regression
Main finding
As reported in the abstract
Fatigue T-score (PROMIS-29 v2.0)
Mean fatigue T-score (SD 11.0) vs general population mean 50
54.6
Mild fatigue
438
18%
Moderate fatigue
641
27%
Severe fatigue
180
8%
Observational data: associations, not effects.
Further findings
Factors independently associated with fatigue T-score (points; 95% CI)
- Age, per year
- −0.10 (−0.14, −0.07)
- Male sex
- −1.67 (−2.96, −0.37)
- Non-married status
- 0.97 (0.04, 1.89)
- France vs USA
- −2.35 (−3.48, −1.21)
- UK vs USA
- 2.38 (0.80, 3.97)
- Smoking
- 4.16 (2.52, 5.80)
- Alcohol, per drink per week
- −0.18 (−0.28, −0.07)
- BMI, per unit
- 0.34 (0.27, 0.42)
- Gastrointestinal involvement
- 4.21 (2.99, 5.43)
- Digital ulcers
- 1.51 (0.25, 2.77)
- Moderate small joint contractures
- 1.41 [0.13, 2.69]
- RA
- 4.34 (2.37, 6.31)
- SS
- 1.89 (0.23, 3.55)
- Multivariable linear regression
Model including pain: factors associated with fatigue T-score (points; 95% CI)
- Pain
- 2.19 (2.03, 2.34)
- ILD
- 1.21 (0.42, 2.00)
Original publication
Fatigue levels and associated factors in systemic sclerosis: a cross-sectional study of 2385 SPIN Cohort participants. Rheumatology (Oxford). Published 24 October 2024. doi:10.
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