Lupus & antiphospholipid syndrome
Headache in systemic lupus erythematosus: The LUNA registry cross-sectional study
Authors' conclusion
This study suggests that photosensitivity is a relevant manifestation of headache in patients with SLE. Persistent hypocomplementemia can contribute to headache-induced disability in daily life, whereas a rash may be a dominant manifestation in patients presenting with moderate/severe headache-induced disability.
Study context
- Population
- Patients with systemic lupus erythematosus (SLE) in a Japanese multicentre cohort (LUNA registry); median age 45 years; female 90.8%
- Participants
- 369 patients
- Exposure
- SLE patients with headache vs without headache
- HAn = 113
- Outcome
- Clinically relevant factors for headache
Methodological detailsmulticentre, registry, multivariate logistic regression
- Multicentre
- Registry
- Multivariate logistic regression
Main finding
As reported in the abstract
Factors associated with headache (multivariate logistic regression)
Age, OR
0.93
95% CI 0.95–0.99
Photosensitivity, OR
2.11
95% CI 1.29–3.49
Observational data: associations, not effects.
Further findings
Factors for headache-induced disability (Migraine Disability Assessment (MIDAS)) in HA patients
- Hypocomplementemia and disability of more than mild grade, OR
- 2.89 (95% CI 1.14-7.74)
- Rash significantly observed in those with moderate and severe disability
Original publication
Headache in systemic lupus erythematosus: The LUNA registry cross-sectional study. Lupus. Published 9 May 2024. doi:10.
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