Lupus & antiphospholipid syndrome
Frequency of sarcopenia in Turkish women with systemic lupus erythematosus
Authors' conclusion
Sarcopenia is prevalent among Turkish women with SLE, with a significant proportion showing reduced muscle strength. The study found no direct association between sarcopenia and SLE disease activity or clinical parameters.
Study context
- Population
- Turkish women with SLE and healthy controls, Gazi University Hospital Department of Rheumatology, January–December 2020
- Participants
- 82 vs 69
- Exposure
- Women with SLE vs healthy controls
- SLEn = 82
- Healthy controlsn = 69reference
- Outcome
- Presence of sarcopenia and probable sarcopenia (2018 European Working Group on Sarcopenia in Older People criteria, Turkish cut-offs), HGS values, skeletal muscle mass index and SLEDAI-2K
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
| Group | Value | Sarcopenia |
|---|---|---|
| SLE | 51.2% | 12.9% |
SLE
Value51.2%
Sarcopenia12.9%
Observational data: associations, not effects.
Further findings
- Hand grip strength (HGS), mean — SLE
- mean 21.7 ± 4.9 kg
Hand grip strength (HGS), mean
- Mean HGS significantly lower in SLE vs controls, indicating reduced muscle strength
Prevalence of anti-double-stranded DNA (anti-dsDNA) antibodies
- Prevalence of anti-dsDNA antibodies
- 82.9%
Independent predictors of probable sarcopenia (multivariate regression)
- Height and anti-dsDNA antibody levels identified as independent predictors of probable sarcopenia
Association of clinical parameters, incl. SLEDAI-2K, with sarcopenia status
- No significant association between clinical parameters, incl. SLEDAI-2K scores, and sarcopenia status
Original publication
Frequency of sarcopenia in Turkish women with systemic lupus erythematosus. Lupus Sci Med. Published 8 May 2024. doi:10.
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