Lupus & antiphospholipid syndrome
Glymphatic abnormality in systemic lupus erythematosus detected by diffusion tensor image analysis along the perivascular space
Authors' conclusion
The non-invasive ALPS index could serve as a sensitive and effective neuroimaging biomarker for individually quantifying glymphatic activity in patients with SLE. Glymphatic system abnormality may be involved in the pathophysiologic mechanism underlying CNS damage in SLE patients.
Study context
- Population
- Female patients with SLE and healthy controls
- Participants
- 45 vs 30
- Exposure
- Female patients with SLE vs healthy controls
- SLEn = 45
- Healthy controls (HCs)n = 30reference
- Outcome
- Glymphatic activity measured by the DTI-ALPS index (ALPS index)
Main finding
As reported in the abstract
ALPS index, whole brain
SLE
1.486
± 0.121
HCs
1.635
± 0.139
P < 0.001
Observational data: associations, not effects.
Further findings
| Outcome | SLE | HCs | P value |
|---|---|---|---|
| ALPS index, left brainLower in SLE | 1.543 ± 0.141 | 1.713 ± 0.175 | P < 0.001 |
| ALPS index, right brainLower in SLE | 1.428 ± 0.142 | 1.556 ± 0.139 | P < 0.001 |
Correlation of ALPS index with grey matter loss
- Reduced ALPS index showed significant positive correlations with grey matter loss
Original publication
Glymphatic abnormality in systemic lupus erythematosus detected by diffusion tensor image analysis along the perivascular space. Rheumatology (Oxford). Published 6 May 2024. doi:10.
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