Lupus & antiphospholipid syndrome
Cortical thickness and diffusion tensor imaging in patients with neuropsychiatric systemic lupus erythematosus, with normal structure on brain magnetic resonance imaging (MRI)
Authors' conclusion
Cortical thickness measurements and DTI analyses can be used to detect differential variations in patients with NPSLE who exhibit an otherwise normal brain structure on conventional MRI, indicating the existence of subtle changes despite the absence of obvious macrostructural central nervous system involvement of lupus.
Study context
- Population
- Female patients with neuropsychiatric systemic lupus erythematosus (NPSLE) whose brain morphology appeared normal on conventional MRI, and female healthy controls
- Participants
- 27 vs 34
- Exposure
- NPSLE with normal conventional MRI vs healthy controls
- NPSLEn = 27
- Healthy controlsn = 34reference
- Outcome
- Regional volumes, cortical thickness and diffusion tensor imaging (DTI) parameters (fractional anisotropy (FA) and mean diffusivity)
Methodological detailsage-adjusted multivariable logistic regression
- Age-adjusted multivariable logistic regression
Main finding
As reported in the abstract
- No significant differences in grey or white matter volume fractions between the groups
- NPSLE vs Healthy controls: P = 0.007
- NPSLE vs Healthy controls: P = 0.001
- NPSLE vs Healthy controls: P = 0.012
- NPSLE vs Healthy controls: P = 0.009
- NPSLE vs Healthy controls: P = 0.005
Observational data: associations, not effects.
Original publication
Cortical thickness and diffusion tensor imaging in patients with neuropsychiatric systemic lupus erythematosus, with normal structure on brain MRI. Lupus. Published 4 February 2023. doi:10.
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