Lupus & antiphospholipid syndrome
Clinical outcome in patients with suspected inflammatory neuropsychiatric lupus treated with immunosuppression: an observational cohort study
Authors' conclusion
The outcome of inflammatory NPSLE after immunosuppressive treatment is generally good, with improvement of neuropsychiatric symptoms occuring in approximately 70% of events.
Study context
- Population
- Patients with SLE at the Leiden University Medical Centre neuropsychiatric SLE (NPSLE) clinic, 2007–2021, receiving immunosuppressive therapy for neuropsychiatric symptoms101 NPSLE events
- Participants
- 95 patients
- Outcome
- Outcome of NP symptoms scored on a 7-point Likert scale (death to resolved) by two independent readers
- Follow-up
- Short-term (0-6 months) and long-term (7-24 months)
Methodological detailssingle-centre, tertiary referral centre, multidisciplinary consensus
- Single-centre
- Tertiary referral centre
- Multidisciplinary consensus
Main finding
As reported in the abstract
Short-term outcome of NP symptoms (Likert scale) · 0-6 months
- Improvement
- 73%
- Improved
- 22%
- Much improved
- 29%
- Resolved
- 22%
- No change
- 21%
- Worsening
- 6%
Observational data: associations, not effects.
Further findings
Long-term outcome of NP symptoms (Likert scale) · 7-24 months
- Improvement
- 70%
- Improved
- 14%
- Much improved
- 28%
- Resolved
- 28%
- No change
- 17%
- Worsening
- 10%
- Death
- 3%
- Available for 78 out of 101 events
Most common NP manifestation: cognitive dysfunction
- Cognitive dysfunction
- 50%
Treatment modalities
- Induction
- 24%
- Induction and maintenance
- 73%
- Other therapy
- 3%
- Prednisone
- 97%
- Methylprednisolone
- 53%
- AZA
- 49%
- CYC
- 42%
Death (long-term) · 7-24 months
- Death
- 3%
- None directly NPSLE-related
Original publication
Clinical outcome in patients with suspected inflammatory neuropsychiatric lupus treated with immunosuppression: an observational cohort study. Lupus Sci Med. Published 3 February 2023. doi:10.
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