Genome-wide association meta-analysis of knee and hip osteoarthritis uncovers genetic differences between patients treated with joint replacement and patients without joint replacement
Authors' conclusion
Our results indicate differences in genetic associations between knee and hip osteoarthritis depending on joint replacement status.
Study context
- Population
- Knee and hip OA cases and healthy controls>700,000 individuals
- Comparison
- Knee and hip OA cases with joint replacement (surgical) vs without joint replacement (non-surgical), each vs healthy controls
- Surgical knee OAn = 22,525
- Non-surgical knee OAn = 38,626
- Surgical hip OAn = 20,221
- Non-surgical hip OAn = 17,847
- Outcome
- Genetic associations (sequence variants) of knee and hip OA by joint replacement status
Methodological detailsfour genome-wide association meta-analyses, genetic correlation analysis with pain phenotypes
- Four genome-wide association meta-analyses
- Genetic correlation analysis with pain phenotypes
Pooled result
As reported in the abstract
Sequence variants associated with knee or hip OA
Surgical knee OA
17
events
Non-surgical knee OA
3
events
Surgical hip OA
34
events
Non-surgical hip OA
1
events
- Total sequence variants identified
- 52
- Novel variants for surgical phenotypes, incl. rs2447606 in ATG7 (autophagy) and rs202127176 in PIEZO1 (mechanotransduction)
- 10
Further pooled results
Genetic correlation with pain phenotypes (intervertebral disc disorder, dorsalgia, FM, migraine, joint pain)
- Genetic correlations with pain phenotypes tended to be stronger in non-surgical groups
Original publication
Genome-wide association meta-analysis of knee and hip osteoarthritis uncovers genetic differences between patients treated with joint replacement and patients without joint replacement. Ann Rheum Dis. Published 14 November 2022. doi:10.
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