A Genome‐Wide Association Study Meta‐Analysis of Alpha Angle Suggests Cam‐Type Morphology May Be a Specific Feature of Hip Osteoarthritis in Older Adults
An erratum to this article was published (Arthritis Rheumatol, Sep 2023 ↗)
Authors' conclusion
Evidence of bidirectional associations between AA and hip OA, particularly for risk of hip OA on AA, suggests that hip shape modeling secondary to a genetic predisposition to hip OA contributes to the well-established relationship between hip OA and cam morphology in older adults.
Study context
- Population
- UK Biobank participants with hip DXA-derived alpha angle (AA) measurements, and the Rotterdam StudyGenome-wide association study (GWAS) meta-analysis
- Participants
- 44,214 participants
- Outcome
- Genetic architecture of cam morphology (AA as proxy) and causal relationship of AA with hip OA
Methodological detailsobservational analyses in UK Biobank, linkage disequilibrium score regression, 2-sample Mendelian randomization (MR)
- Observational analyses in UK Biobank
- Linkage disequilibrium score regression
- 2-sample MR
Pooled result
As reported in the abstract
- Causal effect of AA on hip osteoarthritis (OA) risk (weak evidence), inverse variance weighted OR (95% CI 1.14, 2.96), P = 0.01
- 1.84
- Causal effect of genetic predisposition for hip OA on increased AA (stronger evidence), inverse variance weighted β (95% CI 0.04, 0.13), P = 4.58 × 10-5
- 0.09
- Heritability of AA
- 10%
- Genetic correlation of AA with hip OA (moderate), rg
- 0.26 (95% CI 0.10, 0.43)
- Independent genetic signals associated with AA
- 8
Further pooled results
Observational: AA and radiographic hip OA (UK Biobank)
- Adjusted OR
- 1.63 (95% CI 1.58, 1.67)
Observational: AA and total hip replacement (UK Biobank)
- aHR
- 1.45 (95% CI 1.33, 1.59)
Original publication
A Genome‐Wide Association Study Meta‐Analysis of Alpha Angle Suggests Cam‐Type Morphology May Be a Specific Feature of Hip Osteoarthritis in Older Adults. Arthritis Rheumatol. Published 9 April 2023. doi:10.
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