A meta-analysis and a functional study support the influence of mitochondrial DNA (mtDNA) variant m.16519C on the risk of rapid progression of knee osteoarthritis
Pooled result · Rapid progression of knee OA with mtDNA variant m.16519CResult — go to the resultCombined OR 1.546 95% CI 1.163–2.054Authors' conclusion
The presence of the mtDNA variant m.16519C increases the risk of rapid progression of knee OA.
Study context
- Population
- Subjects with knee osteoarthritis (OA) from three prospective cohorts3 cohorts
- Participants
- 1,095 / 373 / 326
- Comparison
- Carriers vs non-carriers of mtDNA variant m.16519C
- Osteoarthritis initiative (OAI)n = 1,095
- Cohort Hip and Cohort Kneen = 373
- PROspective Cohort of Osteoarthritis from A Coruñan = 326
- Outcome
- Rapid progression of knee OA
Methodological detailsthree prospective cohorts, in-depth mtDNA sequencing, transmitochondrial cybrid model
- Three prospective cohorts
- In-depth mtDNA sequencing
- Transmitochondrial cybrid model
Pooled result
As reported in the abstract
Rapid progression of knee OA with mtDNA variant m.16519C
Combined OR
1.546
95% CI 1.163–2.054
P = 0.0027
Carriersvs non-carriers of mtDNA variant m.16519C
combined OR 1.546 (95% CI 1.163–2.054); P = 0.0027
Further pooled results
Functional study in cybrids with m.16519C
- Increased mtDNA copy number and decreased mitochondrial biosynthesis
- Higher mitochondrial reactive oxygen species (ROS); less resistant to oxidative stress
- Lower expression of fission mitochondrial 1; impaired autophagic flux
- Modulated transcriptome, especially inflammation; IL-6 among most differentially expressed genes
Original publication
A meta-analysis and a functional study support the influence of mtDNA variant m.16519C on the risk of rapid progression of knee osteoarthritis. Ann Rheum Dis. Published 6 April 2023. doi:10.
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