Quantifying sustained pain worsening in knee osteoarthritis
Authors' conclusion
Most participants with knee OA reported at least one clinically relevant increase in WOMAC pain, but fewer than half experienced an episode of sustained pain worsening.
Study context
- Population
- Participants from the Osteoarthritis Initiative with radiographic, symptomatic knee osteoarthritis (OA)
- Participants
- 1,093 participants
- Outcome
- Frequency and duration of episodes of pain worsening (clinically relevant increase: WOMAC pain ≥9 points; sustained worsening: maintaining ≥80% of the initial increase)
Methodological detailsPoisson regression
- Poisson regression
Main finding
As reported in the abstract
Episodes of pain worsening
- ≥1 increase in WOMAC pain ≥9 points
- Eighty-eight percent
- Incidence rate (IR) of WOMAC pain increase ≥9 points
- 26.3 per 100 person years (95% CI: 25.2, 27.4)
- ≥1 episode of sustained worsening
- Forty-eight percent
- IR of sustained worsening
- 9.7 per 100 person-years (95% CI: 8.9, 10.5)
- Average duration elevated pain maintained after initial increase
- 2.4 years
Observational data: associations, not effects.
Original publication
Quantifying sustained pain worsening in knee osteoarthritis. Osteoarthritis Cartilage. Published 5 April 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →