Circulating microRNAs (miRNAs) in hand osteoarthritis
Authors' conclusion
The profile of circulating miRNAs could unveil candidate biomarkers associated with hand OA symptoms.
Study context
- Population
- Patients with hand osteoarthritis (OA) and age- and sex-matched healthy controls
- Participants
- 238 patients
- Comparison
- Hand OA vs age- and sex-matched healthy controls
- Erosive hand OAn = 96
- Non-erosive hand OAn = 73
- Healthy controlsn = 69reference
- Outcome
- Circulating plasma miRNAs
Methodological detailsage- and sex-matched healthy controls, two-phase validation (QuantStudio and SmartChip quantitative real-time PCR (qRT-PCR))
- Age- and sex-matched healthy controls
- Two-phase validation (QuantStudio and SmartChip qRT-PCR)
Main finding
As reported in the abstract
Circulating plasma miRNAs, hand OA vs healthy controls
miRNAs different between hand OA and healthy controls in screening cohort (of 754)
40
After two-phase validation, miR-23a-3p, miR-146a-5p and miR-652-3p increased in hand OA vs healthy controls
3
Observational data: associations, not effects.
Further findings
Association with symptoms
- miR-23a-3p, miR-146a-5p and miR-652-3p associated with AUSCAN sum score and AUSCAN pain
Association with radiographic score
- Inverse correlation of miR-222-3p with Kallman radiographic score
Erosive vs non-erosive hand OA
- miRNA expression did not differ between erosive and non-erosive hand OA
Original publication
Circulating miRNAs in hand osteoarthritis. Osteoarthritis Cartilage. Published 13 November 2022. doi:10.
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