Evaluation of circulating microRNA signature in patients with erosive hand osteoarthritis: The HOAmiR study
Authors' conclusion
We found that miR-196-5p was down-regulated in patients with erosive HOA and some of its targets could explain a role in OA.
Study context
- Population
- Patients with erosive hand osteoarthritis (HOA), non-erosive HOA and controls without HOA, matched for age and body mass index (BMI)screening 30 sera
- Comparison
- Erosive HOA vs non-erosive HOA vs controls without HOA
- Non-erosive HOAn = 10
- Outcome
- Circulating micro-RNAs differentially expressed in erosive HOA vs non-erosive HOA and without HOA
Methodological detailstwo-phase: screening and validation, matched for age and BMI, FDR correction (Benjamini-Hochberg)
- Two-phase: screening and validation
- Matched for age and BMI
- FDR correction (Benjamini-Hochberg)
Main finding
As reported in the abstract
Circulating micro-RNA expression, erosive HOA vs without HOA
Screening: down-regulated micro-RNAs, erosive HOA vs controls
21
Screening: up-regulated micro-RNAs, erosive HOA vs controls
4
Of these, previously described in chondrocyte homeostasis or OA (miR-373-3p, miR-558, miR-607, miR-653-5p, miR-137, miR448 down; miR-142-3p, miR-144-3p, miR-34a-5p up)
9
Observational data: associations, not effects.
Further findings
Significantly down-regulated micro-RNAs, erosive vs non-erosive HOA (screening)
- Only one significantly down-regulated micro-RNA
- 1
Predicted interactions of miR-196-5p
- Could interact with bone homeostasis and HOXC8
- Literature review and miRNA-gene interaction prediction model
Original publication
Evaluation of circulating microRNA signature in patients with erosive hand osteoarthritis: The HOAmiR study. Osteoarthritis Cartilage. Published 8 July 2024. doi:10.
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