Lupus & antiphospholipid syndrome
Genetics of Neonatal Lupus Erythematosus Risk and Specific Manifestations
Authors' conclusion
In a multiethnic cohort of infants and anti-Ro antibody-positive mothers, we did not identify a significant association between SLE genetics and risk of NLE outcomes.
Study context
- Population
- Infants and anti-Ro antibody-positive mothers from a tertiary care clinic
- Participants
- 332 infants253 mother-infant pairs
- Exposure
- Association of systemic lupus erythematosus (SLE) polygenic risk scores with neonatal lupus erythematosus (NLE) outcomes
- Outcome
- Any NLE manifestations, cardiac NLE and cutaneous NLE
Methodological detailstertiary care clinic, multiethnic cohort, polygenic risk scores, HLA-wide analyses
- Tertiary care clinic
- Multiethnic cohort
- Polygenic risk scores
- HLA-wide analyses
Main finding
As reported in the abstract
Association of SLE-PRS with NLE outcomes
- No significant associations between infant polygenic risk scores (PRS), maternal PRS, or maternal-infant PRS difference and any NLE outcomes
- HLA-wide analyses did not identify NLE risk alleles
Observational data: associations, not effects.
Further findings
NLE prevalence among infants
- Any NLE
- 53%
- Cardiac NLE
- 7.2%
- Cutaneous NLE
- 11.7%
Original publication
Genetics of Neonatal Lupus Erythematosus Risk and Specific Manifestations. J Rheumatol. Published 1 June 2024. doi:10.
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