Lupus & antiphospholipid syndrome
Genetics of longitudinal kidney function in children and adults with systemic lupus erythematosus
Authors' conclusion
We observed significant associations between SLE and eGFR PRSs and repeated eGFR measurements, in a large cohort of children and adults with SLE.
Study context
- Population
- Children and adults with SLE (≥4 ACR and/or SLICC criteria) from two tertiary care lupus clinics37% biopsy-confirmed LN
- Participants
- 1,158 children
- Exposure
- SLE and estimated glomerular filtration rate (eGFR) polygenic risk scores vs repeated eGFR measures
- Outcome
- Association of SLE- and eGFR-PRSs with eGFR mean and variance
Methodological detailstwo tertiary care lupus clinics, polygenic risk scores, longitudinal repeated eGFR measures, 36 733 eGFR measures over a median of 7.6 years (IQR: 3.9-15.3)
- Two tertiary care lupus clinics
- Polygenic risk scores
- Longitudinal repeated eGFR measures
- 36 733 eGFR measures over a median of 7.6 years (IQR: 3.9-15.3)
Main finding
As reported in the abstract
Association of polygenic risk scores (PRSs) with eGFR mean and variance
- Increasing SLE-PRSs associated with lower mean eGFR and greater variance
- Increasing eGFR-PRS associated with increased eGFR mean and variance
Observational data: associations, not effects.
Further findings
Within-person mean eGFR, LN vs non-LN
P < 0.0001
Within-person eGFR variance, LN vs non-LN
P < 0.0001
Original publication
Genetics of longitudinal kidney function in children and adults with systemic lupus erythematosus. Rheumatology (Oxford). Published 14 March 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →