Genetic link between rheumatoid arthritis and autoimmune liver diseases: A two-sample Mendelian randomization study
Authors' conclusion
Using a two-sample MR analysis, we investigated the relationship between AILDs and RA and revealed first that PBC increases the risk of RA.
Study context
- Population
- Genome-wide association study (GWAS) datasets for autoimmune liver diseases and rheumatoid arthritis (RA)
- Comparison
- Genetically predicted autoimmune liver diseases (primary biliary cholangitis (PBC), primary sclerosing cholangitis (PSC)) and risk of RA, and the reverse direction
- Outcome
- RA risk per genetically predicted AILD (inverse-variance weighted (IVW))
Methodological detailsinverse-variance weighted primary analysis, four sensitivity analysis methods, MR-Egger regression, leave-one-out
- Inverse-variance weighted primary analysis
- Four sensitivity analysis methods
- MR-Egger regression
- Leave-one-out
Main finding
As reported in the abstract
IVW OR (95% CI)P value
PBC
1.149(1.063–1.241)
P < 0.001PSC
1.071(0.984–1.166)
P = 0.111Per genetically predicted AILD, as printed
- MR-Egger intercept (PBC→RA): horizontal pleiotropy unlikely
- −0.028
Further findings
Reverse direction: genetically predicted RA and risk of PBC or PSC
| OR (95% CI) | P value | ||
|---|---|---|---|
| RA → PBC | 1.132 (0.881–1.454) | P = 0.333 | |
| RA → PSC | 1.067 (0.891–1.279) | P = 0.088 | |
| 0.512Odds ratio (log scale) |
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Genetic link between rheumatoid arthritis and autoimmune liver diseases: A two-sample Mendelian randomization study. Semin Arthritis Rheum. Published 24 November 2022. doi:10.
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