Impact of disease duration on proteomic bioprofile and prognosis in rheumatoid arthritis patients
Main finding · Subsequent CV hospitalisation or CV deathResult — go to the resultHazard ratio 2.71 95% CI 1.06–6.92Authors' conclusion
RA patients with longer disease duration had more organ damage and worse outcomes than those with shorter disease duration.
Study context
- Population
- Rheumatoid arthritis (RA) patients with detailed clinical, echocardiographic and proteomic phenotyping
- Participants
- 399 patients
- Exposure
- Tertiles of RA disease duration
- Outcome
- CV hospitalisation or CV death
Methodological detailsCox proportional models, comparison across tertiles of RA disease duration
- Cox proportional models
- Comparison across tertiles of RA disease duration
Main finding
Subsequent CV hospitalisation or CV death
Hazard ratio
2.71
95% CI 1.06–6.92
P = 0.04
Tertile 3vs Tertile 1
HR 2.71 (95% CI 1.06–6.92); P = 0.04
As reported in the abstract
Observational data: associations, not effects.
Further findings
Clinical characteristics, tertile 3 vs tertile 1
- Tertile 3 older, more erosive disease, more frequent echocardiographic alterations, lower haemoglobin and shorter 6MWT distance
Biomarkers
- Natriuretic peptides, cathepsin L1, galectin 9, MMP-12, adrenomedullin and TNF receptor 11A higher with longer disease duration
Original publication
Impact of disease duration on proteomic bioprofile and prognosis in rheumatoid arthritis patients. Clin Exp Rheumatol. Published 24 November 2022. doi:10.
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