Exploring the causal association between rheumatoid arthritis and the risk of cervical cancer: a two-sample Mendelian randomization study
Main finding · Cervical cancer (IVW analysis)Result — go to the resultOdds ratio 1.096 95% CI 1.018–1.180Authors' conclusion
There is a causal relationship between rheumatoid arthritis and the occurrence of cervical cancer.
Study context
- Population
- Publicly accessible genome-wide association summary data on RA and cervical cancer (MR base database)
- Exposure
- Genetically predicted RA vs no RA
- Outcome
- Cervical cancer risk (susceptibility)
Methodological detailsgenome-wide association summary data (MR base database), inverse variance weighted, weighted median, weighted mode and MR-Egger regression
- Genome-wide association summary data (MR base database)
- Inverse variance weighted, weighted median, weighted mode and MR-Egger regression
Main finding
Cervical cancer (IVW analysis)
Odds ratio
1.096
95% CI 1.018–1.180
P = 0.015
Genetically predicted RAvs no RA
OR 1.096 (95% CI 1.018–1.180); P = 0.015
As reported in the abstract
Observational data: associations, not effects.
Further findings
Horizontal pleiotropy (MR-Egger intercept)
- MR-Egger intercept
- 0.00025, P = 0.574
- Absence of horizontal pleiotropic effects
Heterogeneity
- QEgger
- 2.239
- I2Egger
- 0.225
- PEgger
- 0.268
- QIVW
- 2.734
- I2IVW
- 0.220
- PIVW
- 0.999
- Absence of heterogeneity
Sensitivity analysis and other methods
- Support that genetic pleiotropy does not introduce bias
Original publication
Exploring the causal association between rheumatoid arthritis and the risk of cervical cancer: a two-sample Mendelian randomization study. Arthritis Res Ther. Published 23 January 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →