PD-1 signaling uncovers a pathogenic subset of T cells in inflammatory arthritis
Authors' conclusion
We concluded that PD-1+ HLA-DRHIGH KLRG1LOW T cells are a potential target for future PD-1 agonists to treat inflammatory diseases.
Study context
- Population
- T cells from peripheral blood and synovial fluid of patients with RA
- Outcome
- Genes related to PD-1 inhibition of T cell functions (genome-wide CRISPR/Cas9 screen)
Methodological detailsgenome-wide CRISPR/Cas9 screen, flow cytometry, bulk and single-cell RNA sequencing datasets
- Genome-wide CRISPR/Cas9 screen
- Flow cytometry
- Bulk and single-cell RNA sequencing datasets
Main finding
As reported in the abstract
Additional unique genes related to PD-1 ability to inhibit T cell functions identified
1112
Genes downregulated in activated and effector T cells from synovial fluids in RA single-cell RNA sequencing data (KLRG1, CRTAM, SLAMF7, PTPN2, KLRD1)
5
Original publication
PD-1 signaling uncovers a pathogenic subset of T cells in inflammatory arthritis. Arthritis Res Ther. Published 22 January 2024. doi:10.
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