Pregnancy outcomes in women with rheumatoid arthritis: an 11-year French nationwide study
Authors' conclusion
Pregnancies in women with RA were associated with more adverse outcomes, especially if the disease was active.
Study context
- Population
- All pregnancies ending between 2010 and 2020 in patients with and without rheumatoid arthritis (RA), Francepregnancies
- Exposure
- RA pregnancies vs non-RA pregnancies; active vs non-active RA
- RAn = 11,792
- Non-RAn = 10,413,681reference
- Outcome
- Pregnancy outcomes, RA vs non-RA
Methodological detailsnationwide, French National Health Data System, multivariable logistic marginal regression with generalised estimating equation (GEE)
- Nationwide
- French National Health Data System
- Multivariable logistic marginal regression with GEE
Main finding
As reported in the abstract
Each group vs Non-RAEstimate (95% CI)
RA
aOR, preterm birth 1.84(1.69–2.00)
RA
aOR, very preterm birth 1.43(1.20–1.71)
RA
aOR, low birth weight 1.65(1.52–1.90)
RA
aOR, caesarean section 1.46(1.38–1.55)
RA
aOR, pregnancy-related hospitalisation 1.30(1.22–1.39)
Observational data: associations, not effects.
Further findings
| Outcome | Estimate | |
|---|---|---|
| Pregnancy outcomes, active vs non-active RAActive RAvs Non-active RA | aOR, prematurity 2.02 (95% CI 1.71–2.38) | |
| Pregnancy outcomes, active vs non-active RAActive RAvs Non-active RA | aOR, small for gestational age 1.53 (95% CI 1.28–1.83) | |
| Pregnancy outcomes, active vs non-active RAActive RAvs Non-active RA | aOR, caesarean section 1.25 (95% CI 1.11–1.40) | |
| 0.512Ratio (log scale) |
Outcomes of RA pregnancies
- Live births
- 74.5%
- Stillbirths
- 0.4%
Disease activity during pregnancy
- Disease activity decreased during pregnancy
Original publication
Pregnancy outcomes in women with rheumatoid arthritis: an 11-year French nationwide study. RMD Open. Published 19 January 2024. doi:10.
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