Associations Between Rheumatoid Arthritis Clinical Factors and Synovial Cell Types and States
Authors' conclusion
In this comprehensive screen of clinical factors, we observed differential associations between DMARDs and cell phenotypes
Study context
- Population
- Patients with active rheumatoid arthritis (RA) not receiving disease-modifying antirheumatic drugs (DMARDs) or with inadequate response to methotrexate (MTX) or TNFi (AMP RA study)75% women
- Participants
- 72 patients
- Outcome
- Correlations between RA clinical factors, synovial cell type percentage and CTAPs
Methodological detailssynovial biopsy, CITE-seq
- Synovial biopsy
- CITE-seq
Main finding
As reported in the abstract
- Higher DAS28-CRP3 correlated with higher T cell percentage
- P < 0.01
- MTX without bDMARD: higher B cell percentage vs no DMARDs
- P < 0.01
- bDMARD recipients categorized as endothelial, fibroblast, and myeloid (EFM)
- 57%
- bDMARD recipients categorized as TF
- 0
Observational data: associations, not effects.
Original publication
Associations Between Rheumatoid Arthritis Clinical Factors and Synovial Cell Types and States. Arthritis Rheumatol. Published 19 January 2024. doi:10.
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