Enhanced lipolysis in synovial fibroblasts mark early pathogenic changes in rheumatoid arthritis (RA)-risk individuals
Authors' conclusion
Overall, these findings suggest that early lipid metabolic alterations in SFs represent important shifts in cellular function that precedes clinical disease
Study context
- Population
- Synovial fibroblasts (SFs) from RA-risk individuals, patients with RA and osteoarthritis (OA), and age-matched noninflammatory orthopaedic injury controls
- Comparison
- SFs from RA-risk individuals, RA and OA vs age-matched noninflammatory orthopaedic injury controls
Methodological detailsage-matched controls
- Age-matched controls
Main finding
As reported in the abstract
- RA and RA-risk SFs: distinct transcriptional signatures vs controls, incl. dysregulation of lipid metabolism
- RA, RA-risk and OA SFs: reduced baseline lipid droplet (LD) content vs controls, despite retained adipogenic differentiation potential
- RA and RA-risk SFs: LD reduction due to enhanced LD lipolysis, plausibly from decreased G0S2 expression; reversed by adipose triglyceride lipase inhibition
- Stimulating G0S2 expression coincided with reduced myeloid-supporting SF phenotype
Original publication
Enhanced lipolysis in synovial fibroblasts mark early pathogenic changes in RA-risk individuals. Ann Rheum Dis. Published 30 May 2026. doi:10.
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