Do intrasynovial T lymphocytes facilitate disease progression in patients with rheumatoid arthritis?
Authors' conclusion
In the SF of patients with RA, disease progression was facilitated by formation of doublets between N-DCs and activated effector memory CD4+ T lymphocytes.
Study context
- Population
- Synovial fluid of patients with rheumatoid arthritis (RA)
- Participants
- 15 participants
Methodological detailsflow cytometry, ex-vivo studies
- Flow cytometry
- Ex-vivo studies
Main finding
As reported in the abstract
- Enhanced proportion of activated CD4+ and CD8+ EM T lymphocytes in the synovial fluid (SF), positively correlated with DAS28
- EM T lymphocytes showed enhanced ROS generation, enhanced cytotoxic potential and were CXCR3+/CD28+
- Doublets identified between N-DCs and activated CD4+ EM T lymphocytes
- Ex-vivo: inflammatory milieu facilitated transdifferentiation, T lymphocyte activation and doublet formation
Original publication
Do intrasynovial T lymphocytes facilitate disease progression in patients with rheumatoid arthritis? Clin Exp Rheumatol. Published 4 August 2025. doi:10.
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