Causal relationship between gut microbiota and rheumatoid arthritis: a two-sample Mendelian randomisation study
Authors' conclusion
We identified some specific bacterial taxa that were causally associated with the risk of RA
Study context
- Population
- Publicly available genome-wide association studies (GWAS) of gut microbiota composition and rheumatoid arthritis (RA)GWAS summary data · RA 331,313
- Comparison
- Gut microbiota composition vs RA
- Outcome
- Causal association between gut microbiota taxa and RA (IVW)
Methodological detailsbidirectional, inverse variance weighted (IVW) main method, sensitivity analyses: weighted median, Mendelian randomisation (MR) Egger, MR-PRESSO, Genome-wide threshold 1 × 10-5 in forward MR and 5 × 10-8 in reverse MR
- Bidirectional
- IVW main method
- Sensitivity analyses: weighted median, MR Egger, MR-PRESSO
- Genome-wide threshold 1 × 10-5 in forward MR and 5 × 10-8 in reverse MR
Main finding
As reported in the abstract
Taxa causally associated with RA (IVW)
- MollicutesRF9, positively correlated with RA
- pIVW <0.01
- Alphaproteobacteria, positively correlated with RA
- pIVW <0.01
- Betaproteobacteria, positively correlated with RA
- p IVW =0.04
- Bacteroidaceae, positively correlated with RA
- pIVW <0.01
- Adlercreutzia, positively correlated with RA
- pIVW <0.01
- Bacteroides, positively correlated with RA
- pIVW <0.01
- Butyricimonas, positively correlated with RA
- p IVW =0.03
- Holdemanella, positively correlated with RA
- pIVW =0.03
- Desulfovibrionales, negatively correlated with RA
- pIVW = 0.01
- Methanobacteriales, negatively correlated with RA
- pIVW <0.01
- Methanobacteria, negatively correlated with RA
- PIVW <0.01
- Desulfovibrionaceae, negatively correlated with RA
- pIVW <0.01
- Methanobacteriaceae, negatively correlated with RA
- pIVW <0.01
- Butyrivibrio, negatively correlated with RA
- pIVW =0.02
Further findings
- Heterogeneity
- P > 0.05
- Pleiotropy
- P > 0.05
- Confirmed the robustness of the MR results
Original publication
Causal relationship between gut microbiota and rheumatoid arthritis: a two-sample Mendelian randomisation study. Clin Exp Rheumatol. Published 4 May 2023. doi:10.
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