Causal relationship between rheumatoid arthritis and bronchiectasis: a bidirectional mendelian randomization study
Main finding · Bronchiectasis risk with genetic predisposition to RA, European populations (forward MR, IVW)Result — go to the resultIVW OR 1.28 95% CI 1.20–1.37Authors' conclusion
This study indicates that genetic predisposition to RA correlates with a heightened risk of bronchiectasis in both European and East Asian populations.
Study context
- Population
- Summary statistics for rheumatoid arthritis (RA) and bronchiectasis from the IEU OpenGWAS database; European and East Asian populations
- Comparison
- Genetic predisposition to RA and risk of bronchiectasis (forward), and bronchiectasis and RA (reverse)
- Outcome
- Risk of bronchiectasis with genetic predisposition to RA (forward MR, IVW)
Methodological detailsInverse variance weighting (IVW), MR-Egger, weighted median, weighted mode, simple mode, sensitivity analyses: Cochran's Q test, Mendelian randomization (MR) Egger intercept test, leave-one-out analysis
- IVW, MR-Egger, weighted median, weighted mode, simple mode
- Sensitivity analyses: Cochran's Q test, MR Egger intercept test, leave-one-out analysis
Main finding
As reported in the abstract
Bronchiectasis risk with genetic predisposition to RA, European populations (forward MR, IVW)
IVW OR
1.28
95% CI 1.20–1.37
P = 1.18E-13
Genetic predisposition to RA
IVW OR 1.28 (95% CI 1.20–1.37); P = 1.18E-13
Further findings
Reverse MR: genetic causality of bronchiectasis on RA (European and East Asian populations)
- No evidence to support a genetic causality between bronchiectasis and RA in either European or East Asian populations
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Causal relationship between rheumatoid arthritis and bronchiectasis: a bidirectional mendelian randomization study. Arthritis Res Ther. Published 23 May 2024. doi:10.
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