Rheumatoid arthritis

Rheumatoid arthritis-associated interstitial lung disease: clinical characteristics and mortality in a large single-centre cohort

Clin Exp RheumatolPublished Retrospective cohort study

Authors' conclusion

This study underscores the substantial association between serologies, disease activity scores, and smoking history, contributing to the heightened susceptibility to ILD in RA patients.

Study context

Population
Patients diagnosed with Rheumatoid Arthritis (RA) according to the 2010 ACR/EULAR classification, April 2015 to April 2021
Participants
153 patients
Exposure
RA with interstitial lung disease (ILD) vs RA without ILD
  • RA-ILDn = 53
  • Without ILDn = 100reference
Outcome
Risk factors associated with ILD presence in RA patients
Methodological detailsretrospective chart review, single-centre, multivariable regression
  • Retrospective chart review
  • Single-centre
  • Multivariable regression

Main finding

As reported in the abstract

Factors associated with ILD presence (multivariable analyses)

Smoking status, OR

8.82

Presence of RF, OR

4.98

Elevated DAS28-CRP levels, OR

2.05

Observational data: associations, not effects.

Original publication

Rheumatoid arthritis-associated interstitial lung disease: clinical characteristics and mortality in a large single-centre cohort. Clin Exp Rheumatol. Published 22 May 2024. doi:10.55563/clinexprheumatol/d8m0xv

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