Correlation of Professional Antigen‐Presenting Tbet + CD11c + B Cells With Bone Destruction in Untreated Rheumatoid Arthritis
Authors' conclusion
This study suggests that Tbet+CD11c+ MBCs contribute to the pathogenesis of RA by promoting bone destruction through antigen presentation, T cell activation, and Th17 polarization.
Study context
- Population
- Patients with untreated rheumatoid arthritis (RA) (untreated RA (uRA)); peripheral blood memory B cells (MBCs)Single-cell RNA sequencing (scRNA-seq) n = 4
- Participants
- 36 patients
- Outcome
- Association between CD21-/lowTbet+CD11c+ MBCs and joint destruction and other clinical parameters; functional properties of these cells
Methodological detailsflow cytometry, single-cell RNA sequencing, V(D)J sequencing, in vitro coculture
- Flow cytometry
- Single-cell RNA sequencing
- V(D)J sequencing
- In vitro coculture
Main finding
As reported in the abstract
- Unique signature of up-regulated genes associated with antigen presentation functions, mirrored in synovial counterparts
- >150
Original publication
Correlation of Professional Antigen‐Presenting Tbet + CD11c + B Cells With Bone Destruction in Untreated Rheumatoid Arthritis. Arthritis Rheumatol. Published 21 May 2024. doi:10.
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