Rheumatoid arthritis increases the risk of malignant neoplasm of bone and articular cartilage: a two-sample bidirectional mendelian randomization study
Authors' conclusion
The findings of this study demonstrate that RA constitutes a significant risk factor for MNBAC.
Study context
- Population
- GWAS summary data: Rheumatoid arthritis (RA) from IEU OpenGWAS database; Benign neoplasm of bone and articular cartilage (BNBAC) and malignant neoplasm of bone and articular cartilage (MNBAC) from the Finnish consortium
- Comparison
- Genetically predicted RA vs benign (BNBAC) and malignant (MNBAC) neoplasm of bone and articular cartilage, and reverse
- Outcome
- Causal association between RA and BNBAC and MNBAC
Methodological detailsGWAS summary data, eight Mendelian randomization (MR) methods (random-effects inverse variance weighted (IVW), MR Egger, weighted median, simple mode, weighted mode, maximum likelihood, penalized weighted median, fixed effects IVW)
- GWAS summary data
- Eight MR methods (random-effects IVW, MR Egger, weighted median, simple mode, weighted mode, maximum likelihood, penalized weighted median, fixed effects IVW)
Main finding
As reported in the abstract
RAOdds ratio (95% CI)P value
Outcome BNBAC; no significant genetic association
0.971(0.904–1.044)
P = 0.427Outcome MNBAC; positive genetic association
1.413(1.144–1.745)
P = 0.001Further findings
Reverse MR: BNBAC and MNBAC on RA
| OR (95% CI) | P value | ||
|---|---|---|---|
| BNBACOutcome RA | 1.041 (0.994–1.091) | P = 0.088 | |
| MNBACOutcome RA | 1.013 (0.995–1.031) | P = 0.168 | |
| 0.512Odds ratio (log scale) |
Sensitivity analyses
- No heterogeneity, horizontal pleiotropy or outliers; effect not driven by a single single-nucleotide polymorphism (SNP); data normally distributed
Original publication
Rheumatoid arthritis increases the risk of malignant neoplasm of bone and articular cartilage: a two-sample bidirectional mendelian randomization study. Arthritis Res Ther. Published 13 November 2023. doi:10.
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