Increased Risk of Rheumatoid Arthritis in Patients With Asthma: A Genetic Association Study Using Two‐Sample Mendelian Randomization Analysis
Authors' conclusion
Genetically predicted AOA predisposes patients to an increased risk of rheumatoid arthritis but has no causal effects on osteoarthritis, gout, and ankylosing spondylitis.
Study context
- Population
- Genetic instruments for asthma from a large genome-wide association study of asthma
- Comparison
- Genetically predicted asthma and risk of arthritis
- Outcome
- RA (MR-IVW)
Methodological detailsinverse-variance weighted (IVW) main analysis, Bonferroni-adjusted P value threshold, reverse Mendelian randomization (MR) analysis
- Inverse-variance weighted (IVW) main analysis
- Bonferroni-adjusted P value threshold
- Reverse MR analysis
Main finding
As reported in the abstract
Odds ratio (95% CI)P value
AOA
1.018(1.011–1.025)
P < 0.001COA
1.006(1.001–1.012)
P = 0.046Further findings
Reverse MR: RA on all asthma, allergic asthma or nonallergic asthma
- No significant causal effects
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Increased Risk of Rheumatoid Arthritis in Patients With Asthma: A Genetic Association Study Using Two‐Sample Mendelian Randomization Analysis. Arthritis Care Res (Hoboken). Published 21 September 2023. doi:10.
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